"To the best of my knowledge and from what I have seen so far, each of the actions that were undertaken by State Department officials was entirely appropriate," Pompeo told a news conference.
The whistleblower report released on Thursday said Trump not only abused his office in attempting to solicit Ukraine's interference in the 2020 U.S. election for his own political benefit, but that the White House also tried to "lock down" evidence about that conduct.
Trump has denied wrongdoing.
The report references State Department officials and ambassadors, some by name.
Pompeo said the Trump administration has sought to "create a better relationship between the United States and Ukraine and build on the opportunities to tighten our relationship and help end corruption in Ukraine."