The SpaceX Dragon cargo craft detached from the International Space Station and began its return to earth on Tuesday.
Robotic flight controllers in Houston issued remote commands for its release, backed up by Flight Engineer Christina Koch aboard the ISS, NASA said in a statement.
The spacecraft contains nearly 3,000 pounds of scientific experiments and other cargo.
Among the scientific experiments are are studies in 'bio-mining' in microgravity, research into mosses grown in space compared to on earth, and silica studies.
The 'splashdown' on earth will occur around 300 miles southwest of Long Beach, California, a NASA presenter said during broadcast.