So I'll go back to the womb cancer rates that happened in the 1960s 70s and then we worked out regimens of HRT that would prevent womb cancer and that was fine.
And then the Women's Health Initiative study was set up in the 1990s and early publication in the early 2000s it was looked at women being commenced on it was a randomized double-blind placebo controlled trial and it looked at women being commenced on HRT between the ages of I think around 50 to 76.
And that study showed an increased risk of new breast cancers in the hormone replacement.